Lose weight for sure. I don't want to be thin/skinny, but dropping some weight would help a lot.
A positive attitude may not solve all your problems, but it will annoy enough people to make it worth the effort. Farmgirl Sister #242 http://vintage-moxie.blogspot.com
More time outdoors! Not just because of the exercise, I feel better all around when I'm in real air, experiencing real weather (not the controlled climate of an office building).